Immunotherapy : BKNeutrol
Description Therapy
General information
Today, there is no specific treatment for BK virus. The only strategy currently used by nephrologists is a balance between reactivation of the BK virus and modulation of immunosuppressive treatment.
Our approach
Specific treatment of BK virus is based on a bi-specific antibody directed against the major BK virus capsid protein VP1 . This bi-specific antibody is capable of neutralizing the two most frequent genotypes, I and IV, representing 95% of reactivation cases. Currently in R&D, the next step is to validate the in vitro proof-of-concept so as to be able to start Phase I clinical trials (in the absence of a preclinical efficacy model).
Benefits
In the absence of a specific treatment, SPyDiag aims to optimize therapeutic management by proposing a treatment specifically directed against the major capsid protein of the BK virus. Contrary to current practice, specific treatment will enable the immunosuppressive therapy already in place to be maintained, thus avoiding graft rejection. This specific treatment will therefore reduce graft losses and increase graft life.